金霉素酸：具有不同生物合成基因簇的相似抗生素。
Aureolic acids: similar antibiotics with different biosynthetic gene clusters.
作者信息
O'Connor Sarah
机构信息
Massachusetts Institute of Technology, Cambridge 02139, USA.
出版信息
Chem Biol. 2004 Jan;11(1):8-10. doi: 10.1016/j.chembiol.2004.01.006.
Abstract
In this issue of Chemistry & Biology, Méndez and colleagues describe the sequence and organization of the chromomycin gene cluster. Unexpectedly, the arrangement is starkly different from the mithramycin biosynthetic cluster, despite similarity in the individual genes and the near identical structures of the two antibiotic aureolic acids.
摘要
在本期《化学与生物学》中，门德斯及其同事描述了放线菌素基因簇的序列和组织。出乎意料的是，尽管单个基因存在相似性，且两种抗生素金霉素的结构几乎相同，但该基因簇的排列与光神霉素生物合成簇截然不同。
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