来自三叶五加茎皮的贝壳杉烷型二萜糖苷。
Kaurane-type diterpene glycoside from the stem bark of Acanthopanax trifoliatus.
作者信息
Kiem Phan Van, Cai Xing Fu, Minh Chau Van, Lee Jung Joon, Kim Young Ho
机构信息
Institute of Natural Products Chemistry, NCST, Nghiado, Caugiay, Hanoi, Vietnam.
出版信息
Planta Med. 2004 Mar;70(3):282-4. doi: 10.1055/s-2004-818926.
A new diterpene glycoside, acantrifoside D ( 1), as well as three known diterpenes (2 - 4) were isolated from the stem bark of Acanthopanax trifoliatus from Vietnam. Based on 1D and 2D NMR spectroscopic data, their chemical structures were determined to be 16alpha,17-dihydroxy- ent-kauran-19-oic acid 16- O-beta- D-glucopyranoside 19- O-beta- D-glucopyranosyl ester (1), 16alpha H,17-isovalerate- ent-kauran-19-oic acid (2), ent-kaur-16-en-19-oic acid ( 3), and ent-pimara-8(14),15-dien-19-oic acid (4). Compounds 2 - 4 had strong inhibitory effects against COX-1 in an in vitro assay, with IC50 values of 0.21, 0.15 and 0.19 mM, respectively.
从越南三叶五加的茎皮中分离出一种新的二萜糖苷刺五加苷D（1）以及三种已知的二萜（2 - 4）。根据一维和二维核磁共振光谱数据，确定它们的化学结构分别为16α,17 - 二羟基 - 对映贝壳杉烷 - 19 - 酸16 - O - β - D - 吡喃葡萄糖苷19 - O - β - D - 吡喃葡萄糖基酯（1）、16αH,17 - 异戊酸 - 对映贝壳杉烷 - 19 - 酸（2）、对映贝壳杉 - 16 - 烯 - 19 - 酸（3）和对映海松 - 8(14),15 - 二烯 - 19 - 酸（4）。在体外实验中，化合物2 - 4对COX - 1具有强烈的抑制作用，IC50值分别为0.21、0.15和0.19 mM。
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