来自藤金合欢的类黄酮及其对环氧化酶（COX - 1和COX - 2）的抑制活性。
Flavonoids from Acacia pennata and their cyclooxygenase (COX-1 and COX-2) inhibitory activities.
作者信息
Dongmo Alain B, Miyamoto Tomofumi, Yoshikawa Kazuko, Arihara Shigenobu, Lacaille-Dubois Marie-Aleth
机构信息
Faculté de Pharmacie, Laboratoire de Pharmacognosie, Unité de Molécules d'Intérêt Biologique, UMIB, UPRES-EA 3660, Université de Bourgogne, Dijon, France.
出版信息
Planta Med. 2007 Sep;73(11):1202-7. doi: 10.1055/s-2007-981596. Epub 2007 Sep 7.
Two new flavonoids quercetin 4'-O-alpha-L-rhamnopyranosyl-3-O-beta-D-allopyranoside (1) and apigenin 6-C-[2''-O-(E)-feruloyl- beta-D-glucopyranosyl]-8-C-beta-glucopyranoside (2), along with the known isorhamnetin 3-O-alpha-L-rhamnopyranoside (3), kaempferol 3-O-alpha-L-rhamnopyranosyl-(1-->4)-beta-D-glucopyranoside (4), and isovitexin (5) were isolated from the leaves of Acacia pennata Willd. (Mimosaceae) and tested for their anti-inflammatory activity. Their structures were determined by 1D and 2D NMR and mass spectrometry. They were tested for an inhibitory effect on COX-1 and COX-2, showing 60-90% inhibition at 10(-4) g/mL and 5-14% inhibition at 10(-4) g/mL, respectively.
从藤金合欢（含羞草科）叶中分离得到两个新黄酮类化合物槲皮素4'-O-α-L-鼠李糖基-3-O-β-D-阿洛糖苷（1）和芹菜素6-C-[2''-O-(E)-阿魏酰基-β-D-葡萄糖苷]-8-C-β-葡萄糖苷（2），以及已知化合物异鼠李素3-O-α-L-鼠李糖苷（3）、山柰酚3-O-α-L-鼠李糖基-(1→4)-β-D-葡萄糖苷（4）和异荭草苷（5），并对它们的抗炎活性进行了测试。通过一维和二维核磁共振及质谱确定了它们的结构。测试了它们对COX-1和COX-2的抑制作用，结果显示在10(-4) g/mL时对COX-1的抑制率为60 - 90%，对COX-2的抑制率为5 - 14%。
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