伪动态组合文库：一种受体辅助的药物发现方法。 - Suppr

Suppr

超能文献

Pseudodynamic combinatorial libraries: a receptor-assisted approach for drug discovery.

作者信息

Corbett Andrew D, Cheeseman Jeremy D, Kazlauskas Romas J, Gleason James L

机构信息

Department of Chemistry, McGill University, 801 Sherbrooke St. West, Montréal, QC, H3A 2 K6, Canada.

出版信息

Angew Chem Int Ed Engl. 2004 Apr 26;43(18):2432-6. doi: 10.1002/anie.200453769.

DOI:10.1002/anie.200453769

PMID:15114583

Abstract

摘要

相似文献

Pseudodynamic combinatorial libraries: a receptor-assisted approach for drug discovery.

Angew Chem Int Ed Engl. 2004 Apr 26;43(18):2432-6. doi: 10.1002/anie.200453769.

Amplification of screening sensitivity through selective destruction: theory and screening of a library of carbonic anhydrase inhibitors.

J Am Chem Soc. 2002 May 22;124(20):5692-701. doi: 10.1021/ja017099+.

Discovery of new chromone containing sulfonamides as potent inhibitors of bovine cytosolic carbonic anhydrase.

Bioorg Med Chem. 2011 Jun 1;19(11):3367-71. doi: 10.1016/j.bmc.2011.04.040. Epub 2011 Apr 22.

QSAR study on benzenesulphonamide carbonic anhydrase inhibitors: topological approach using Balaban index.

Bioorg Med Chem. 2004 Feb 15;12(4):789-93. doi: 10.1016/j.bmc.2003.10.058.

Fragment-based drug discovery of carbonic anhydrase II inhibitors by dynamic combinatorial chemistry utilizing alkene cross metathesis.

Bioorg Med Chem. 2006 May 15;14(10):3275-84. doi: 10.1016/j.bmc.2005.12.054. Epub 2006 Jan 20.

In situ click chemistry: enzyme-generated inhibitors of carbonic anhydrase II.

Angew Chem Int Ed Engl. 2004 Dec 17;44(1):116-20. doi: 10.1002/anie.200461580.

Topological modeling of lipophilicity, diuretic activity, and carbonic inhibition activity of benzene sulfonamides: a molecular connectivity approach.

Bioorg Med Chem Lett. 2004 Nov 15;14(22):5661-6. doi: 10.1016/j.bmcl.2004.08.051.

Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II "selective" inhibitor celecoxib.

Bioorg Med Chem Lett. 2006 Jan 15;16(2):437-42. doi: 10.1016/j.bmcl.2005.09.040. Epub 2005 Nov 14.

QSAR study on carbonic anhydrase inhibitors: water-soluble sulfonamides incorporating beta-alanyl moieties, possessing long lasting-intra ocular pressure lowering properties--a molecular connectivity approach.

Eur J Med Chem. 2005 Oct;40(10):1002-12. doi: 10.1016/j.ejmech.2005.04.006. Epub 2005 Jun 14.

Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides.

Bioorg Med Chem. 2009 Jul 15;17(14):5054-8. doi: 10.1016/j.bmc.2009.05.063. Epub 2009 May 30.

引用本文的文献

Light-Fueled Primitive Replication and Selection in Biomimetic Chemical Systems.

J Am Chem Soc. 2023 Jun 21;145(24):13371-13383. doi: 10.1021/jacs.3c03597. Epub 2023 Jun 7.

Mimicking nature with synthetic macromolecules capable of recognition.

Nat Chem. 2014 Aug;6(8):665-72. doi: 10.1038/nchem.1994.

Nucleophilic catalysis of acylhydrazone equilibration for protein-directed dynamic covalent chemistry.

Nat Chem. 2010 Jun;2(6):490-7. doi: 10.1038/nchem.658. Epub 2010 May 16.

Dynamic template-assisted strategies in fragment-based drug discovery.

Trends Biotechnol. 2009 Sep;27(9):512-21. doi: 10.1016/j.tibtech.2009.06.001. Epub 2009 Aug 11.

Direct screening of a dynamic combinatorial library using mass spectrometry.

J Am Soc Mass Spectrom. 2006 Aug;17(8):1074-1080. doi: 10.1016/j.jasms.2006.03.017. Epub 2006 Jun 2.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验