小脑浦肯野细胞中长时程抑制诱导的数学模拟
Mathematical simulation of the induction of long-term depression in cerebellar Purkinje cells.
作者信息
Murzina G B
机构信息
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.
出版信息
Neurosci Behav Physiol. 2004 Feb;34(2):115-21. doi: 10.1023/b:neab.0000009205.08547.10.
Abstract
The question of the mechanisms underlying the induction of associative and homosynaptic long-term depression in cerebellar Purkinje cells is addressed. Mathematical simulation was used to investigate the possibility that long-term depression, which is associated with a decrease in the efficiency of AMPA receptors, could be induced both by phosphorylation and dephosphorylation of these receptors.
摘要
本文探讨了小脑浦肯野细胞中联合性和同突触性长时程抑制诱导机制的问题。采用数学模拟来研究与AMPA受体效率降低相关的长时程抑制是否可由这些受体的磷酸化和去磷酸化诱导产生。
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