发现二芳基丙烯腈作为一类新型小分子分选酶A抑制剂。

Discovery of diarylacrylonitriles as a novel series of small molecule sortase A inhibitors.

作者信息

Oh Ki-Bong, Kim Soo-Hwan, Lee Jaekwang, Cho Won-Jea, Lee Taeho, Kim Sanghee

机构信息

Natural Products Research Institute, College of Pharmacy, Seoul National University, 28 Yungun, Jongro, Seoul 110-460, Korea.

出版信息

J Med Chem. 2004 May 6;47(10):2418-21. doi: 10.1021/jm0498708.

DOI:10.1021/jm0498708

PMID:15115384

Abstract

On the basis of a hit from random screening, a novel class of small-molecule sortase A inhibitors was generated. The primary structure-activity relationship and the minimal structural requirements for potency were established through structural modifications and molecular modeling studies.

摘要

基于随机筛选中的一个命中结果，产生了一类新型的小分子分选酶A抑制剂。通过结构修饰和分子建模研究，建立了初步的构效关系以及活性所需的最小结构要求。