Grossman Zahi, Branski David
Harefuah. 2004 Apr;143(4):277-82, 318, 317.
Acute Otitis Media (AOM) is the most common reason for pediatrician's visits and for antibiotic prescription in childhood. A significant rise in bacterial resistance to antibiotic treatment has been detected in recent years. Accordingly, the attitude towards antibiotic treatment for AOM has been re-evaluated. Due to various difficulties in ear examination, physicians overdiagnosis Otitis Media with Effusion (OME) as AOM, leading to unnecessary prescription of antibiotics. The natural history of AOM shows spontaneous improvement without complications. Studies that have examined antibiotic treatment versus placebo in AOM have shown only minimal advantage for the antibiotic therapy in symptom reduction. Critical appraisal of the literature according to Evidence-based Medicine (EBM) criteria has led to several meta-analyses that showed only a minor advantage for antibiotics over placebo in AOM. In the Netherlands, the approach to AOM is that of delayed prescribing: symptomatic therapy is given for the first 24-72 hours and an antibiotic drug is prescribed only if symptoms persist after this initial period. This review examines the difficulties in reaching an accurate diagnosis of AOM and describes the natural history of AOM and evaluates the studies and meta-analyses comparing antibiotics to placebo. The Dutch approach to AOM will be discussed as an option and a recommended basis for reduction in antibiotic prescriptions for AOM.
急性中耳炎(AOM)是儿科医生问诊及儿童期抗生素处方的最常见原因。近年来已检测到细菌对抗生素治疗的耐药性显著上升。因此,对AOM抗生素治疗的态度已重新评估。由于耳部检查存在各种困难,医生将分泌性中耳炎(OME)过度诊断为AOM,导致不必要的抗生素处方。AOM的自然病程显示可自发改善且无并发症。在AOM中对比抗生素治疗与安慰剂的研究表明,抗生素治疗在减轻症状方面仅具有极小的优势。根据循证医学(EBM)标准对文献进行的批判性评估已产生多项荟萃分析,结果显示在AOM中抗生素仅比安慰剂具有轻微优势。在荷兰,对AOM的治疗方法是延迟开药:在最初的24 - 72小时进行对症治疗,只有在这段初始时间后症状仍持续时才开具抗生素药物。本综述探讨了准确诊断AOM的困难,描述了AOM的自然病程,并评估了对比抗生素与安慰剂的研究及荟萃分析。将讨论荷兰对AOM的治疗方法,作为减少AOM抗生素处方的一种选择和推荐依据。