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疟疾基因组计划及其对该疾病的影响。

Malaria genome project and its impact on the disease.

作者信息

Verma Poonam, Sharma Y D

机构信息

Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India.

出版信息

J Vector Borne Dis. 2003 Mar-Jun;40(1-2):9-15.

Abstract

Malaria remains uncontrolled to-date due to lack of effective parasite and vector control strategies. With the completion of the host, parasite and vector genome projects more suitable and effective disease control measures can be achieved. Here we have reviewed the Plasmodium falciparum genome project and its impact on malaria research in future. The parasite genome project has revealed certain metabolic pathways which can be targeted to develop antimalarial drugs. It has also identified large number of potential antigens for the future potential vaccines. Now the researchers in the malaria field can plan to take up the studies, which can yield more fruitful results within the limited financial resources using bioinformatics, proteomics, structural, functional and comparative genomics, etc.

摘要

由于缺乏有效的寄生虫和病媒控制策略,疟疾至今仍未得到有效控制。随着宿主、寄生虫和病媒基因组计划的完成,可以实现更合适、有效的疾病控制措施。在此,我们回顾了恶性疟原虫基因组计划及其对未来疟疾研究的影响。寄生虫基因组计划揭示了某些可作为抗疟药物靶点的代谢途径。它还确定了大量未来潜在疫苗的潜在抗原。现在,疟疾领域的研究人员可以计划开展相关研究,利用生物信息学、蛋白质组学、结构、功能和比较基因组学等,在有限的财政资源内取得更丰硕的成果。

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