Kahl Ulrika
Human Brain Informatics samt institutionen för medicinsk epidemiologi, Karolinska institutet, Stockholm.
Lakartidningen. 2003 Mar 20;100(12):1042-7.
Every year, malaria kills between 1 and 2 million people. Another half billion get infected but survive. Most cases of malaria are found in sub-Saharan Africa. Because of drug and insecticide resistance and social and environmental changes the problems are still increasing. There is therefore a desperate need for vaccines and new drugs and insecticides. Several recently published research discoveries may help to speed up the development of new tools to fight malaria. Two years ago the draft human genome sequence was released. Now the sequencing of the genomes for the most common malaria parasite, Plasmodium falciparum, and the vector mosquito, Anopheles gambiae, have been completed. For the first time researchers have the genomic maps of all three organisms in an infectious disease available.
每年，疟疾导致100万至200万人死亡。另有5亿人感染但存活下来。大多数疟疾病例出现在撒哈拉以南非洲地区。由于耐药性、抗杀虫剂能力以及社会和环境变化，这些问题仍在加剧。因此，迫切需要疫苗、新药和杀虫剂。最近发表的几项研究发现可能有助于加快抗击疟疾新工具的研发。两年前发布了人类基因组序列草图。现在，最常见的疟原虫——恶性疟原虫以及传播媒介蚊子——冈比亚按蚊的基因组测序已经完成。研究人员首次获得了一种传染病中所有三种生物体的基因组图谱。
