心脏诱导：从胚胎学到心肌细胞再生

Heart induction: embryology to cardiomyocyte regeneration.

作者信息

Foley Ann, Mercola Mark

机构信息

Ann Foley and Mark Mercola are at the Stem Cell and Regeneration Program, The Burnham Institute, La Jolla, California, USA.

出版信息

Trends Cardiovasc Med. 2004 Apr;14(3):121-5. doi: 10.1016/j.tcm.2004.01.003.

DOI:10.1016/j.tcm.2004.01.003

PMID:15121161

Abstract

Developmental biologists have uncovered many of the signaling proteins that are required to recruit early embryonic cells to the myocardial lineage. A detailed understanding of their function should provide insights into the difficult task of inducing embryonic stem cells to develop cardiomyocyte precursors for cell-based therapies. These proteins may also prove to be useful to stimulate progenitor cells to differentiate into cardiomyocytes within the damaged heart.

摘要

发育生物学家已经发现了许多将早期胚胎细胞招募到心肌谱系所需的信号蛋白。对其功能的详细了解应该有助于深入了解诱导胚胎干细胞发育成心肌细胞前体以用于细胞疗法这一艰巨任务。这些蛋白质也可能被证明有助于刺激祖细胞在受损心脏内分化为心肌细胞。