Vasavada Abhay R, Raj Shetal M
Iladevi Cataract & IOL Research Centre, Raghudeep Eye Clinic, Ahmedabad, India.
Ophthalmology. 2004 May;111(5):886-94. doi: 10.1016/j.ophtha.2003.08.039.
To evaluate the relationship of the anterior capsule and the AcrySof MA30BA intraocular lens (IOL) and its impact on the development of central posterior capsule opacification (PCO).
Prospective, randomized, controlled trial.
Two hundred two patients with senile cataracts received an AcrySof IOL between July and December 1998 at Iladevi Cataract and IOL Research Center, Ahmedabad, India.
Patients were randomized prospectively to receive 1 of the 3 possibilities of anterior capsule and IOL optic relationship: group 1, total anterior capsule cover (360 degrees ) of the optic; group 2, no anterior capsule cover (360 degrees ) of the optic; group 3, partial anterior capsule cover (<360 degrees ) of the optic. After surgery, slit-lamp video photography was performed every 6 months for 3 years. Analyses of variance and chi-square tests were used to compare treatment groups.
Incidence of PCO in the 3 groups. The posterior capsule was divided into 3 zones: peripheral, central 3 mm, and midperipheral (the space between the peripheral and the central zones).
The average follow-up was 35.3 +/- 1.52 months in all the groups. At 3 years, the rate of central PCO was 6.4% in group 1, 7.1% in group 2, and 5.9% in group 3 (P = 0.9). Midperipheral PCO was present in 24.2% in group 1, 16% in group 2, and 20.6% in group 3 (P = 0.9). Peripheral PCO was seen in 100% of patients in all groups. The neodynium:yttrium-aluminum-garnet laser (Nd:YAG) posterior capsulotomy rate was 0% in all groups.
There was no significant difference in the incidence of development of central PCO among the 3 groups. No patient experienced central PCO that required Nd:YAG capsulotomy. When using the AcrySof IOL model MA30BA, the relationship of the anterior capsule and the IOL does not seem to be a factor that relates to the development of central PCO.
评估前囊膜与AcrySof MA30BA人工晶状体（IOL）的关系及其对中央后囊膜混浊（PCO）发展的影响。
前瞻性、随机、对照试验。
1998年7月至12月期间，202例老年性白内障患者在印度艾哈迈达巴德的伊拉德维白内障与IOL研究中心接受了AcrySof IOL植入。
患者被前瞻性随机分为3组，接受前囊膜与IOL光学部关系的3种情况之一：第1组，光学部完全被前囊膜覆盖（360度）；第2组，光学部无前囊膜覆盖（360度）；第3组，光学部部分被前囊膜覆盖（<360度）。术后3年，每6个月进行一次裂隙灯视频摄影。采用方差分析和卡方检验比较各治疗组。
3组中PCO的发生率。后囊膜分为3个区域：周边区、中央3mm区和中周边区（周边区与中央区之间的区域）。
所有组的平均随访时间为35.3±1.52个月。3年后，第1组中央PCO的发生率为6.4%，第2组为7.1%，第3组为5.9%（P = 0.9）。第1组中周边区PCO的发生率为24.2%，第2组为16%，第3组为20.6%（P = 0.9）。所有组100%的患者出现周边区PCO。所有组的钕：钇铝石榴石激光（Nd:YAG）后囊膜切开率均为0%。
3组中央PCO的发生率无显著差异。没有患者因中央PCO需要进行Nd:YAG后囊膜切开术。使用AcrySof IOL模型MA30BA时，前囊膜与IOL的关系似乎不是与中央PCO发展相关的因素。
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