基于血红蛋白的氧载体在严重贫血治疗中的应用。

Use of a hemoglobin-based oxygen carrier in the treatment of severe anemia.

作者信息

Shander Aryeh, Alalawi Raed, Seeber Petra, Lui John

机构信息

Department of Anesthesiology and Critical Care Medicine, Englewood Hospital and Medical Center, Englewood, New Jersey 07631, USA.

出版信息

Obstet Gynecol. 2004 May;103(5 Pt 2):1096-9. doi: 10.1097/01.AOG.0000121828.69264.53.

DOI:10.1097/01.AOG.0000121828.69264.53

PMID:15121621

Abstract

BACKGROUND

Hemoglobin-based oxygen carriers hold promise for the treatment of acute anemia.

CASE

We report a patient with severe dysfunctional uterine bleeding. During her hospitalization, her lowest hemoglobin level was 3.1 g/dL, with a hematocrit of 9.3%. An investigational product, o-raffinose cross-linked human hemoglobin solution (hemoglobin raffimer), was infused along with ongoing high-dose recombinant human erythropoietin and estrogen. The time until the patient's own hematopoiesis provided sufficient red blood cell mass was successfully managed by reducing oxygen demand and providing multiple hemoglobin-based oxygen carrier infusions. After hemoglobin-based oxygen carrier administration, transient pulmonary hypertension and fever were noted. She was discharged after corrective surgery 7 days after hemoglobin-based oxygen carrier administration with a hemoglobin level of 7.8 g/dL.

CONCLUSION

The hemoglobin level-based oxygen carrier improved oxygen delivery and permitted uterine corrective surgery.

摘要

背景

基于血红蛋白的氧载体有望用于治疗急性贫血。

病例

我们报告一名严重功能失调性子宫出血患者。住院期间，她的最低血红蛋白水平为3.1 g/dL，血细胞比容为9.3%。一种研究性产品，o-棉子糖交联人血红蛋白溶液（血红蛋白 raffimer），与持续的高剂量重组人促红细胞生成素和雌激素一起输注。通过降低氧需求并多次输注基于血红蛋白的氧载体，成功地控制了患者自身造血提供足够红细胞量所需的时间。给予基于血红蛋白的氧载体后，出现了短暂性肺动脉高压和发热。在给予基于血红蛋白的氧载体7天后进行矫正手术后，她出院时血红蛋白水平为7.8 g/dL。