败血梭状芽孢杆菌所致全眼球炎
Panophthalmitis due to clostridium septicum.
作者信息
Schickner Daniel C, Yarkoni Alon, Langer Paul, Frohman Larry, Chen Xue, Folberg Robert, Del Priore Lucian V
机构信息
Department of Ophthalmology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ, USA.
出版信息
Am J Ophthalmol. 2004 May;137(5):942-4. doi: 10.1016/j.ajo.2003.10.030.
PURPOSE
To describe patient survival in a rare case of endogenous Clostridium septicum sepsis with panophthalmitis.
DESIGN
Observational case report.
METHODS
Both eyes of a female patient were examined in a hospital setting.
RESULTS
A 68-year-old woman had right orbital pain, proptosis, panophthalmitis, mental confusion and fever for 2 days. Blood cultures were significant for Clostridium septicum. The patient did not improve after treatment with intravenous broad-spectrum antibiotics and the right eye was enucleated. The patient survived the acute infection and extensive systemic evaluation revealed an undiagnosed colon carcinoma that may have been responsible for colonization and vascular dissemination of Clostridium septicum.
CONCLUSIONS
Clostridium septicum panophthalmitis and sepsis can be the presenting sign in patients with unsuspected malignancies, particularly colon cancer. Patients can survive the infection with aggressive therapy with systemic antibiotics combined with removal of the infected tissue.
目的
描述一例罕见的伴有全眼球炎的内源性败血梭菌败血症患者的生存情况。
设计
观察性病例报告。
方法
在医院环境中对一名女性患者的双眼进行检查。
结果
一名68岁女性出现右眼眶疼痛、眼球突出、全眼球炎、精神错乱和发热2天。血培养显示败血梭菌阳性。静脉注射广谱抗生素治疗后患者病情未改善，右眼被摘除。患者在急性感染中存活下来，广泛的全身评估发现了一处未被诊断出的结肠癌，可能是败血梭菌定植和血行播散的原因。
结论
败血梭菌性全眼球炎和败血症可能是未被怀疑患有恶性肿瘤（尤其是结肠癌）患者的首发症状。通过积极的全身抗生素治疗并结合切除感染组织，患者可以在感染中存活下来。
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