酿酒酵母SSD1-V通过一种不依赖Sir2p的机制赋予细胞长寿特性。
Saccharomyces cerevisiae SSD1-V confers longevity by a Sir2p-independent mechanism.
作者信息
Kaeberlein Matt, Andalis Alex A, Liszt Gregory B, Fink Gerald R, Guarente Leonard
机构信息
Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA.
出版信息
Genetics. 2004 Apr;166(4):1661-72. doi: 10.1534/genetics.166.4.1661.
Abstract
The SSD1 gene of Saccharomyces cerevisiae is a polymorphic locus that affects diverse cellular processes including cell integrity, cell cycle progression, and growth at high temperature. We show here that the SSD1-V allele is necessary for cells to achieve extremely long life span. Furthermore, addition of SSD1-V to cells can increase longevity independently of SIR2, although SIR2 is necessary for SSD1-V cells to attain maximal life span. Past studies of yeast aging have been performed in short-lived ssd1-d strain backgrounds. We propose that SSD1-V defines a previously undescribed pathway affecting cellular longevity and suggest that future studies on longevity-promoting genes should be carried out in long-lived SSD1-V strains.
摘要
酿酒酵母的SSD1基因是一个多态性位点，它影响多种细胞过程，包括细胞完整性、细胞周期进程以及在高温下的生长。我们在此表明，SSD1-V等位基因是细胞实现极长寿命所必需的。此外，如果将SSD1-V添加到细胞中，可独立于SIR2增加寿命，尽管SIR2对于SSD1-V细胞达到最大寿命是必需的。过去对酵母衰老的研究是在寿命较短的ssd1-d菌株背景下进行的。我们提出，SSD1-V定义了一条以前未被描述的影响细胞寿命的途径，并建议未来对长寿促进基因的研究应在长寿的SSD1-V菌株中进行。
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