Bruno R, Ghisolfi L, Priulla M, Nicolin A, Bertelli A
Department of Pharmacology, University of Milan, Italy.
Drugs Exp Clin Res. 2003;29(5-6):257-61.
In modern industrial societies the attention to public health, especially in relation to food habits, is increasing day by day. Considering this, it's no wonder that wine, the voluptuary drink that best represents human history, is the most interesting compound. The main and best known wine effects on the human body are caused by alcohol, but several other active compounds are present in wine. Above all, resveratrol is able to neutralize free radicals, which can damage DNA and may lead to cancer onset. In this study, we have indagated resveratrol anticancer action, analyzing its effects on both cell cycle and growing of human lymphoma B (DHL-4) cells. MTT colorimetric test, tripan blue dye exclusion assay, and cell cycle analysis showed that resveratrol has a dose-dependent antiproliferative and antiapoptotic action on DHL-4 cells. These results confirm resveratrol's potential therapeutic role on tumors.
在现代工业社会中，对公众健康的关注，尤其是与饮食习惯相关的关注，正与日俱增。考虑到这一点，葡萄酒作为最能代表人类历史的纵情享受饮品，成为最有趣的化合物也就不足为奇了。葡萄酒对人体的主要且最为人熟知的影响是由酒精引起的，但葡萄酒中还存在其他几种活性化合物。最重要的是，白藜芦醇能够中和自由基，自由基会损害DNA并可能导致癌症的发生。在本研究中，我们探究了白藜芦醇的抗癌作用，分析了其对人类淋巴瘤B（DHL - 4）细胞的细胞周期和生长的影响。MTT比色法、台盼蓝染料排除试验和细胞周期分析表明，白藜芦醇对DHL - 4细胞具有剂量依赖性的抗增殖和抗凋亡作用。这些结果证实了白藜芦醇在肿瘤治疗方面的潜在作用。
