人工肝支持分子吸附剂循环系统疗法作为两例长无肝期患者再次移植的桥梁。
Artificial liver support molecular adsorbents recirculating system therapy as a bridge to re-transplantation in two cases of long anhepatic duration.
作者信息
Liu Yi-He, Wang Yu, Yu Li-Xin, Sun Li-Ying, Feng Bao-Lan, Shen Zhong-Yang, Wang Min-Min
机构信息
Tianjin Organ Transplantation Institute, Tianjin First Central Hospital, Tianjin 300192, China.
出版信息
Hepatobiliary Pancreat Dis Int. 2004 May;3(2):316-7.
BACKGROUND
Molecular adsorbents recirculating system (MARS) liver support therapy is the development of albumin dialysis. This study was to assess the successful application of MARS artificial liver support therapy as a bridge to re-transplantation in two cases of long anhepatic duration.
METHODS
MARS therapy was given after failure plasma-exchange (PE) treatment, which resulted in circulatory derangement and acute renal dysfunction in a 36-year-old male patient. Finally his uncontrolled anhepatic condition led to a successful re-transplantation. In another 48-year-old man who was diagnosed as having primary nonfunction (PNF) during the liver transplantation, 10-hour MARS treatment contributed to smooth bridging of his anhepatic phase.
RESULTS
The two anhepatic patients were bridged for 26 and 17 hours respectively to re-transplantation with MARS therapy.
CONCLUSION
Our experience proves that MARS artificial liver can be an effective support for long time bridging PNF until re-transplantation is available.
背景
分子吸附剂循环系统（MARS）肝脏支持疗法是白蛋白透析技术的发展。本研究旨在评估MARS人工肝支持疗法在两例长无肝期病例中作为再次移植桥梁的成功应用。
方法
在一名36岁男性患者血浆置换（PE）治疗失败后给予MARS治疗，该治疗导致循环紊乱和急性肾功能不全。最终，他无法控制的无肝状态导致了成功的再次移植。在另一例48岁男性患者中，其在肝移植过程中被诊断为原发性无功能（PNF），10小时的MARS治疗有助于顺利度过其无肝期。
结果
两名无肝患者分别通过MARS治疗作为桥梁，在等待再次移植期间维持了26小时和17小时。
结论
我们的经验证明，MARS人工肝可以有效地长时间支持PNF患者，直至能够进行再次移植。
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