[Preparation of liposomes surface-modified with glycyrrhetinic acid targeting to hepatocytes].

OBJECTIVE

To study the preparation of liposomes surface-modified with glycyrrhetinic acid targeting to hepatocytes.

METHOD

3-succinic-30-stearyl glycyrrhetinic acid(Suc-GAOSt), one of the amphiphilic glycyrrhetinic acid derivatives, was synthesized as targeting molecules, liposomes surface-modified with glycyrrhetinic acid has been produced with ethanol injection method.

RESULT

Targeting molecules can be mixed into the liposomal membrane. It was confirmed that the targeting molecules is 9% of the total lipids at the most in the liposomes.

CONCLUSION

Liposomes surface-modified with glycyrrhetinic acid was successfully prepared, which is considered to be a potential approach targeting to hepatocytes.