脂质体作为药用天然产物的多功能纳米载体
Liposomes as Multifunctional Nano-Carriers for Medicinal Natural Products.
作者信息
Cheng Xiamin, Yan Hui, Pang Songhao, Ya Mingjun, Qiu Feng, Qin Pinzhu, Zeng Chao, Lu Yongna
机构信息
Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University (Nanjing Tech), Nanjing, China.
School of Environment and Ecology, Jiangsu Open University, Nanjing, China.
出版信息
Front Chem. 2022 Aug 8;10:963004. doi: 10.3389/fchem.2022.963004. eCollection 2022.
Although medicinal natural products and their derivatives have shown promising effects in disease therapies, they usually suffer the drawbacks in low solubility and stability in the physiological environment, low delivery efficiency, side effects due to multi-targeting, and low site-specific distribution in the lesion. In this review, targeted delivery was well-guided by liposomal formulation in the aspects of preparation of functional liposomes, liposomal medicinal natural products, combined therapies, and image-guided therapy. This review is believed to provide useful guidance to enhance the targeted therapy of medicinal natural products and their derivatives.
尽管药用天然产物及其衍生物在疾病治疗中已显示出有前景的效果，但它们通常存在一些缺点，如在生理环境中的低溶解度和稳定性、低递送效率、多靶点导致的副作用以及在病变部位的低特异性分布。在本综述中，脂质体制剂在功能性脂质体的制备、脂质体药用天然产物、联合治疗以及图像引导治疗等方面为靶向递送提供了良好的指导。相信本综述将为增强药用天然产物及其衍生物的靶向治疗提供有益的指导。
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