在逆转录病毒诱导的小鼠免疫缺陷中，疾病诱导需要CD40相关的TRAF 6信号传导。
CD40-associated TRAF 6 signaling is required for disease induction in a retrovirus-induced murine immunodeficiency.
作者信息
Green Kathy A, Ahonen Cory L, Cook W James, Green William R
机构信息
Department of Microbiology and Immunology, 1 Medical Center Dr., Dartmouth Medical School, Lebanon, NH 03750, USA.
出版信息
J Virol. 2004 Jun;78(11):6055-60. doi: 10.1128/JVI.78.11.6055-6060.2004.
Abstract
LP-BM5 retrovirus-infected C57BL/6 mice develop splenomegaly, lymphadenopathy, hypergammaglobulinemia, and immunodeficiency; thus, this disease has been named mouse AIDS. In this syndrome, CD154/CD40 interactions are required for but do not mediate disease by upregulation of CD80 or CD86. We report here that there is nonetheless a necessity for CD40 signaling competence, specifically an intact tumor necrosis factor receptor-associated factor 6 (TRAF 6) binding site.
摘要
LP-BM5逆转录病毒感染的C57BL/6小鼠会出现脾肿大、淋巴结病、高球蛋白血症和免疫缺陷；因此，这种疾病被命名为小鼠艾滋病。在这种综合征中，CD154/CD40相互作用是必需的，但不是通过上调CD80或CD86来介导疾病。我们在此报告，尽管如此，CD40信号传导能力仍然是必需的，特别是一个完整的肿瘤坏死因子受体相关因子6（TRAF 6）结合位点。
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