逆转录病毒诱导的小鼠免疫缺陷综合征所需的CD154/CD40相互作用不是由共刺激分子CD80/CD86的上调介导的。
The CD154/CD40 interaction required for retrovirus-induced murine immunodeficiency syndrome is not mediated by upregulation of the CD80/CD86 costimulatory molecules.
作者信息
Green Kathy A, Cook W James, Sharpe Arlene H, Green William R
机构信息
Department of Microbiology and Immunology and the Norris Cotton Cancer Center, Dartmouth Medical School, Borwell Building, Lebanon, NH 03756, USA.
出版信息
J Virol. 2002 Dec;76(24):13106-10. doi: 10.1128/jvi.76.24.13106-13110.2002.
Abstract
C57BL/6 (B6) mice infected with LP-BM5 retroviruses develop disease, including an immunodeficiency similar to AIDS. This disease, murine AIDS (MAIDS), is inhibited by in vivo anti-CD154 monoclonal antibody treatment. The similar levels of insusceptibility of CD40(-/-) and CD154(-/-) B6 mice indicate that CD154/CD40 molecular interactions are required for MAIDS. CD4(+) T and B cells, respectively, provide the CD154 and CD40 expression needed for MAIDS induction. Here, the required CD154/CD40 interaction is shown to be independent of CD80 and CD86 expression: CD80/CD86(-/-) B6 mice develop MAIDS after LP-BM5 infection.
摘要
感染LP - BM5逆转录病毒的C57BL/6（B6）小鼠会发病，包括出现一种类似于艾滋病的免疫缺陷。这种疾病，即鼠类艾滋病（MAIDS），可通过体内抗CD154单克隆抗体治疗得到抑制。CD40（-/-）和CD154（-/-）B6小鼠的不敏感性水平相似，这表明MAIDS需要CD154/CD40分子相互作用。CD4（+）T细胞和B细胞分别提供MAIDS诱导所需的CD154和CD40表达。在此，已表明所需的CD154/CD40相互作用独立于CD80和CD86表达：CD80/CD86（-/-）B6小鼠在感染LP - BM5后会患上MAIDS。
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