Brucknerová I, Benedeková M, Pechán I, Franková E, Ujházy E, Dubovický M
1st Department of Paediatrics, Medical School, Comenius University, Bratislava, Slovak Republic.
Cent Eur J Public Health. 2004 Mar;12 Suppl:S18-20.
The aim of the present study was to investigate influence of oxidative stress on newborn organism, in terms of the dynamics of malondialdehyde (MDA) concentration changes and of the activities of selected antioxidants in asphyxial newborns on the 1st and 5th day of life.
In the group of 62 preterm and term asphyxial newborns, characterized by the presence of asphyxial criteria and admitted within 24 hours of life, the plasma concentration of MDA and level of total antioxidant status (TAS) were followed.
Dynamic changes of MDA signalized active process of lipoperoxidation (LP) and values of TAS were decreased in comparison with the capacity of adult patients.
本研究旨在从丙二醛（MDA）浓度变化动态以及窒息新生儿出生第1天和第5天所选抗氧化剂活性方面，探讨氧化应激对新生机体的影响。
在62例早产和足月窒息新生儿组中，这些新生儿具有窒息标准且在出生后24小时内入院，对其血浆MDA浓度和总抗氧化状态（TAS）水平进行跟踪监测。
MDA的动态变化表明存在活跃的脂质过氧化（LP）过程，与成年患者的能力相比，TAS值降低。
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