平滑肌中的肌浆网、Ca2+捕获及波动机制
The sarcoplasmic reticulum, Ca2+ trapping, and wave mechanisms in smooth muscle.
作者信息
McCarron John G, Bradley Karen N, MacMillan Debbi, Chalmers Susan, Muir Thomas C
机构信息
Institute of Biomedical and Life Sciences, Neuroscience and Biomedical Systems, University of Glasgow, Glasgow G12 8QQ, Scotland, UK.
出版信息
News Physiol Sci. 2004 Jun;19:138-47. doi: 10.1152/nips.01518.2004.
The sarcoplasmic reticulum (SR) and apposed regions of the sarcolemma passively trap Ca2+ entering the cell to limit the rise in cytoplasmic Ca2+ concentration without SR pump involvement. When "leaky," the SR facilitates Ca2+ entry to the cytoplasm. SR Ca2+ release via inositol 1,4,5-trisphosphate receptors (IP(3)Rs) propagates as calcium waves; IP(3)Rs alone account for wave propagation.
肌浆网（SR）和肌膜的相邻区域被动捕获进入细胞的Ca2+，以限制细胞质Ca2+浓度的升高，而无需肌浆网泵的参与。当“渗漏”时，肌浆网促进Ca2+进入细胞质。通过肌醇1,4,5-三磷酸受体（IP(3)Rs）释放的肌浆网Ca2+以钙波的形式传播；仅IP(3)Rs就负责波的传播。
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