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平滑肌中肌醇-1,4,5-三磷酸诱导肌浆网释放钙离子对鸟苷三磷酸的需求。

GTP requirement for inositol-1,4,5-trisphosphate-induced Ca2+ release from sarcoplasmic reticulum in smooth muscle.

作者信息

Saida K, van Breemen C

出版信息

Biochem Biophys Res Commun. 1987 May 14;144(3):1313-6. doi: 10.1016/0006-291x(87)91453-7.

DOI:10.1016/0006-291x(87)91453-7
PMID:3495274
Abstract

We have examined inositol-1,4,5-trisphosphate (IP3)-induced Ca2+ release from the sarcoplasmic reticulum (SR) in the skinned vascular smooth muscle. The amount of Ca2+ in the SR was estimated indirectly by caffeine-induced contraction of the skinned preparation. The Ca2+ release from the SR by IP3 required GTP. A non-hydrolyzable analogue of GTP, guanosine 5'-(beta gamma-imido) triphosphate (GppNHp) could substitute for GTP in the IP3-induced Ca2+ release. These results suggest an involvement of GTP-binding protein in the mechanism of Ca2+ release from the SR by IP3 in smooth muscle.

摘要

我们研究了在去表皮的血管平滑肌中，肌醇-1,4,5-三磷酸（IP3）诱导的肌浆网（SR）钙释放。通过咖啡因诱导去表皮制剂收缩，间接估计了SR中的钙含量。IP3从SR释放钙需要GTP。GTP的一种不可水解类似物，鸟苷5'-（βγ-亚氨基）三磷酸（GppNHp）可替代GTP参与IP3诱导的钙释放。这些结果表明，GTP结合蛋白参与了平滑肌中IP3诱导SR钙释放的机制。

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