Kordonouri O, Danne T
Klinik für Allgemeine Pädiatrie, Otto-Heubner-Centrum für Kinder- und Jugendmedizin, Charité Universitätsmedizin Berlin, Campus Virchow-Klinikum.
Dtsch Med Wochenschr. 2004 May 14;129(20):1145-8. doi: 10.1055/s-2004-824863.
Coeliac disease (CD) and autoimmune thyreoiditis (AIT) are associated with type-1 diabetes. These diseases frequently occur without apparent clinical symptoms. Therefore, a serological screening by autoantibody testing is required for early detection. Identified by screening, the prevalence of CD and AIT is reported to be up to 10-fold higher in young patients with type-1 diabetes than in healthy children. Up to now, no uniform recommendations exist regarding a standardized screening procedure as well as the treatment of patients with clinically asymptomatic disorder and evidence of autoimmunity. A delay in the detection of associated diseases, however, may lead to clinical relevant, but otherwise preventable complications.
乳糜泻（CD）和自身免疫性甲状腺炎（AIT）与1型糖尿病相关。这些疾病常常在没有明显临床症状的情况下发生。因此，需要通过自身抗体检测进行血清学筛查以实现早期诊断。据报道，通过筛查发现，1型糖尿病年轻患者中CD和AIT的患病率比健康儿童高10倍。到目前为止，对于标准化筛查程序以及临床无症状但有自身免疫证据的患者的治疗，尚无统一的建议。然而，相关疾病检测的延迟可能会导致临床相关但原本可预防的并发症。
