[过氧化物酶体增殖物激活受体γ C-161T基因多态性与代谢综合征患者颈动脉粥样硬化]

[Peroxisome proliferator-activated receptor gamma C-161T polymorphism and carotid artery atherosclerosis in metabolic syndrome].

作者信息

Yan Zhen-cheng, Zhu Zhi-ming, Shen Cheng-yi, Zhao Zhi-gang, Ni Yin-xing, Zhong Jian, Nie Hai

机构信息

Department of Hypertension and Endocrinology and Chongqing Institute of Hypertension, Daping Hospital, The Third Military Medical University, Chongqin 400042, China.

出版信息

Zhonghua Yi Xue Za Zhi. 2004 Apr 2;84(7):543-7.

PMID:15144586

Abstract

OBJECTIVE

To assess the relationship between PPAR gamma C161-T polymorphism and Carotid Atherosclerosis in metabolic Syndrome (MS).

METHODS

Polymerase chain reaction-restricted fragments length polymorphism was used to study the distribution of the PPAR gamma C161-T polymorphism in 248 metabolism syndrome, 163 essential hypertension (EH) and 115 type 2 diabetes mellitus (DM) patients and 121 normal controls. Fasting insulin (FINS), fasting blood glucose (FBG), uric Acid (UA), plasma lipids and ultrasonography for carotid artery were examined.

RESULTS

Waistline and BMI were significantly higher in MS compared with those in control, EH and DM (P < 0.01). systolic blood pressure (SBP), diastolic blood pressure (DBP) and pulse pressure (PP) were markedly higher in MS and EH compared with those in DM and control (P < 0.01). The frequencies of the CC, CT and TT were 74.6%, 21.8% and 3.6% in MS respectively, The frequencies of the CC was significantly higher in MS compared with that in control, but T allele carrier (CT + TT) was significantly lower compared with control, DM and EH (P < 0.05 or P < 0.01). In MS, CC genotype had significantly increased the intima-media thickness (IMT) of common carotid artery and plaque index compared with CT + TT (IMT: 0.84 mm +/- 0.3 mm vs 0.66 mm +/- 0.19 mm; plaque index: 2.19 +/- 1.21 vs 1.66 +/- 1.36, P < 0.05), CC genotype had significantly increased plaque index compared with CT + TT in EH and DM (plaque index: EH: 1.55 +/- 1.23 vs 1.29 +/- 0.92; DM: 1.57 +/- 1.2 vs 1.18 +/- 0.85, P < 0.05); CC genotype had significantly higher SBP compared with CT + TT in EH (P < 0.05), CC genotype had significantly increased plaque index in MS than that in DM and EH (P < 0.01), CC genotype had significantly increased IMT in MS compared with DM. CC genotype had significantly higher SBP and PP compared with CT + TT in MS (SBP: 155 mm Hg +/- 23 mm Hg vs 145 mm Hg +/- 21 mm Hg; PP: 69 mm Hg +/- 8 mm Hg vs 58 mm Hg +/- 8 mm Hg, 1 mm Hg = 0.133 kPa, P < 0.05).

CONCLUSION

In MS, CC genotype was prone to lesion of carotid artery, but CT + TT may reduce lesion of carotid artery, which implicates that PPAR gamma C161-T may play a important role in carotid artery arteriosclerosis.

摘要

目的

评估过氧化物酶体增殖物激活受体γ（PPARγ）C161-T基因多态性与代谢综合征（MS）患者颈动脉粥样硬化之间的关系。

方法

采用聚合酶链反应-限制性片段长度多态性方法，研究248例代谢综合征患者、163例原发性高血压（EH）患者、115例2型糖尿病（DM）患者及121例正常对照者中PPARγ C161-T基因多态性的分布情况。检测空腹胰岛素（FINS）、空腹血糖（FBG）、尿酸（UA）、血脂水平，并进行颈动脉超声检查。

结果

与对照组、EH组和DM组相比，MS组的腰围和体重指数（BMI）显著更高（P < 0.01）。与DM组和对照组相比，MS组和EH组的收缩压（SBP）、舒张压（DBP）和脉压（PP）显著更高（P < 0.01）。MS组中CC、CT和TT基因型的频率分别为74.6%、21.8%和3.6%。与对照组相比，MS组中CC基因型的频率显著更高，但T等位基因携带者（CT + TT）的频率显著低于对照组、DM组和EH组（P < 0.05或P < 0.01）。在MS组中，与CT + TT基因型相比，CC基因型使颈总动脉内膜中层厚度（IMT）和斑块指数显著增加（IMT：0.84 mm ± 0.3 mm vs 0.66 mm ± 0.19 mm；斑块指数：2.19 ± 1.21 vs 1.66 ± 1.36，P < 0.05）；在EH组和DM组中，CC基因型与CT + TT基因型相比，斑块指数显著增加（斑块指数：EH组：1.55 ± 1.23 vs 1.29 ± 0.92；DM组：1.57 ± 1.2 vs 1.18 ± 0.85，P < 0.05）；在EH组中，CC基因型与CT + TT基因型相比，SBP显著更高（P < 0.05）；在MS组中，CC基因型的斑块指数显著高于DM组和EH组（P < 0.01），与DM组相比，MS组中CC基因型使IMT显著增加。在MS组中，CC基因型与CT + TT基因型相比，SBP和PP显著更高（SBP：155 mmHg ± 23 mmHg vs 145 mmHg ± 21 mmHg；PP：69 mmHg ± 8 mmHg vs 58 mmHg ± 8 mmHg，1 mmHg = 0.133 kPa，P < 0.05）。