固定化试剂和清除剂的多步应用：埃坡霉素C的全合成

Multi-step application of immobilized reagents and scavengers: a total synthesis of epothilone C.

作者信息

Storer R Ian, Takemoto Toshiyasu, Jackson Philip S, Brown Dearg S, Baxendale Ian R, Ley Steven V

机构信息

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.

出版信息

Chemistry. 2004 May 17;10(10):2529-47. doi: 10.1002/chem.200305669.

DOI:10.1002/chem.200305669

PMID:15146525

Abstract

The total synthesis of the cytotoxic antitumour natural product epothilone C has provided a stage for the exploitation and further development of immobilized reagent methods. A stereoselective convergent synthetic strategy was applied, incorporating polymer-supported reagents, catalysts, scavengers and catch-and-release techniques to avoid frequent aqueous work-up and chromatographic purification.

摘要

细胞毒性抗肿瘤天然产物埃坡霉素C的全合成，为固定化试剂方法的开发和进一步发展提供了一个平台。采用了立体选择性汇聚合成策略，结合聚合物负载试剂、催化剂、清除剂和捕获-释放技术，以避免频繁的水相后处理和色谱纯化。