酮咯酸与哌替啶及羟嗪治疗急性偏头痛的疗效比较：一项随机、前瞻性、双盲试验

Ketorolac versus meperidine and hydroxyzine in the treatment of acute migraine headache: a randomized, prospective, double-blind trial.

作者信息

Duarte C, Dunaway F, Turner L, Aldag J, Frederick R

机构信息

Department of Emergency Medicine, University of Illinois College of Medicine, Peoria.

出版信息

Ann Emerg Med. 1992 Sep;21(9):1116-21. doi: 10.1016/s0196-0644(05)80654-7.

DOI:10.1016/s0196-0644(05)80654-7

PMID:1514724

Abstract

STUDY OBJECTIVE

To compare the effectiveness of IM ketorolac with that of meperidine and hydroxyzine in the treatment of acute migraine headache.

DESIGN

Prospective, randomized, double-blind trial.

SETTING

Urban emergency department with an annual census of 42,000 patients.

PARTICIPANTS

Forty-seven adult patients with migraines enrolled on 50 visits.

INTERVENTIONS

Patients were randomly assigned to receive a single injection of either 60 mg ketorolac (group 1) or 100 mg meperidine and 50 mg hydroxyzine (group 2). Pain assessment was made using both visual-analog and verbal descriptor scales.

RESULTS

At 60 minutes, 15 patients (60%) from group 1 (25) and 14 patients (56%) from group 2 (25) reported a great deal of complete relief (P = .77) Sixty-minute mean pain relief scores (3.35 versus 3.37) were different (P = .76). Nine patients (36%) from group 1 and seven patients (28%) from group 2 required additional analgesia (P = .76).

CONCLUSION

Ketorolac is as effective as meperidine and hydroxyzine for the treatment of acute migraine headache.

摘要

研究目的

比较肌肉注射酮咯酸与哌替啶和羟嗪治疗急性偏头痛的疗效。

设计

前瞻性、随机、双盲试验。

地点

年接诊量为42000例患者的城市急诊科。

参与者

47例成年偏头痛患者，共就诊50次。

干预措施

患者被随机分配接受单次注射60毫克酮咯酸（第1组）或100毫克哌替啶和50毫克羟嗪（第2组）。使用视觉模拟量表和言语描述量表进行疼痛评估。

结果

60分钟时，第1组（25例）中的15例患者（60%）和第2组（25例）中的14例患者（56%）报告疼痛完全缓解（P = 0.77）。60分钟时的平均疼痛缓解评分（3.35对3.37）有差异（P = 0.76）。第1组中的9例患者（36%）和第2组中的7例患者（28%）需要追加镇痛（P = 0.76）。