作为疼痛临床药理学基础的传播途径和介质。
Transmission pathways and mediators as the basis for clinical pharmacology of pain.
作者信息
Kirkpatrick Daniel R, McEntire Dan M, Smith Tyler A, Dueck Nicholas P, Kerfeld Mitchell J, Hambsch Zakary J, Nelson Taylor J, Reisbig Mark D, Agrawal Devendra K
机构信息
a Departments of Clinical and Translational Science and Anesthesiology , Creighton University School of Medicine , Omaha , NE , USA.
出版信息
Expert Rev Clin Pharmacol. 2016 Oct;9(10):1363-1387. doi: 10.1080/17512433.2016.1204231. Epub 2016 Jul 4.
Mediators in pain transmission are the targets of a multitude of different analgesic pharmaceuticals. This review explores the most significant mediators of pain transmission as well as the pharmaceuticals that act on them. Areas covered: The review explores many of the key mediators of pain transmission. In doing so, this review uncovers important areas for further research. It also highlights agents with potential for producing novel analgesics, probes important interactions between pain transmission pathways that could contribute to synergistic analgesia, and emphasizes transmission factors that participate in transforming acute injury into chronic pain. Expert commentary: This review examines current pain research, particularly in the context of identifying novel analgesics, highlighting interactions between analgesic transmission pathways, and discussing factors that may contribute to the development of chronic pain after an acute injury.
疼痛传导中的介质是多种不同镇痛药的作用靶点。本综述探讨了疼痛传导中最重要的介质以及作用于这些介质的药物。涵盖领域：本综述探讨了疼痛传导的许多关键介质。在此过程中，本综述揭示了有待进一步研究的重要领域。它还强调了具有开发新型镇痛药潜力的药物，探究了可能有助于协同镇痛的疼痛传导途径之间的重要相互作用，并强调了参与将急性损伤转化为慢性疼痛的传导因素。专家评论：本综述审视了当前的疼痛研究，特别是在识别新型镇痛药、强调镇痛传导途径之间的相互作用以及讨论可能导致急性损伤后慢性疼痛发展的因素方面。
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