Pasterkamp G, Van Keulen J K, De Kleijn D P V
University Medical Center, Utrecht, the Netherlands.
Eur J Clin Invest. 2004 May;34(5):328-34. doi: 10.1111/j.1365-2362.2004.01338.x.
The family of Toll-like receptors (TLRs) initiates an innate immune response after recognition of pathogen-associated molecular patterns (PAMPs). Evidence is accumulating that TLRs, and particularly TLR4, are important players in the initiation and progression of atherosclerotic disease. Not only exogenous ligands but also endogenous ligands that are expressed during arterial injury are recognized by TLR4. Mouse knockout studies and epidemiological studies of human TLR4 polymorphisms have demonstrated that the TLR4 might play a role in the initiation and progression of atherosclerosis. This review will summarize the latest progression in research on the role of TLR4 in arterial occlusive disease In addition, the potential of intervention in TLR4 signalling to influence progression of atherosclerotic disease is discussed.
Toll样受体（TLR）家族在识别病原体相关分子模式（PAMP）后启动先天性免疫反应。越来越多的证据表明，TLR，尤其是TLR4，在动脉粥样硬化疾病的发生和发展中起着重要作用。TLR4不仅能识别外源性配体，还能识别动脉损伤期间表达的内源性配体。小鼠基因敲除研究和人类TLR4多态性的流行病学研究表明，TLR4可能在动脉粥样硬化的发生和发展中起作用。本综述将总结TLR4在动脉闭塞性疾病中作用的最新研究进展。此外，还讨论了干预TLR4信号传导以影响动脉粥样硬化疾病进展的潜力。
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