Wakai T, Kanda T, Hirota S, Ohashi A, Shirai Y, Hatakeyama K
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Niigata City 951-8510, Japan.
Br J Cancer. 2004 Jun 1;90(11):2059-61. doi: 10.1038/sj.bjc.6601819.
Currently, there are no data on the secondary resistance of gastrointestinal stromal tumours to imatinib. Here, we report a case of metastatic gastrointestinal stromal tumour that relapsed during imatinib therapy. Mutation analysis showed that the imatinib-resistant liver tumour contained two c-kit mutations.
目前，尚无关于胃肠道间质瘤对伊马替尼继发性耐药的数据。在此，我们报告1例转移性胃肠道间质瘤在伊马替尼治疗期间复发的病例。突变分析显示，对伊马替尼耐药的肝肿瘤含有两个c-kit突变。
Zotero 插件