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金属支架置入术与单次近距离放射治疗在食管癌姑息治疗中的成本研究。

Cost study of metal stent placement vs single-dose brachytherapy in the palliative treatment of oesophageal cancer.

作者信息

Polinder S, Homs M Y V, Siersema P D, Steyerberg E W

机构信息

Department of Public Health, Erasmus MC/University Medical Center Rotterdam, PO Box 1738, 3000 CA Rotterdam, The Netherlands.

出版信息

Br J Cancer. 2004 Jun 1;90(11):2067-72. doi: 10.1038/sj.bjc.6601815.

Abstract

Self-expanding metal stent placement and single-dose brachytherapy are commonly used for the palliation of oesophageal obstruction due to inoperable oesophagogastric cancer. We randomised 209 patients to the placement of an Ultraflex stent (n=108) or single-dose brachytherapy (12 Gy, n=101). Cost comparisons included comprehensive data of hospital costs, diagnostic interventions and extramural care. We acquired detailed information on health care consumption from a case record form and from monthly home visits by a specialised nurse. The initial costs of stent placement were higher than the costs of brachytherapy (1500 euro vs 570 euro; P<0.001). Total medical costs were, however, similar (stent 11 195 euro vs brachytherapy 10 078 euro, P>0.20). Total hospital stay during follow-up was 11.5 days after stent placement vs 12.4 days after brachytherapy, which was responsible for the high intramural costs in both treatment groups (stent 6512 euro vs brachytherapy 7982 euro, P>0.20). Costs for medical procedures during follow-up were higher after stent placement (stent 249 euro vs brachytherapy 168 euro, P=0.002), while the costs of extramural care were similar (1278 euro vs 1046 euro, P>0.20). In conclusion, there are only small differences between the total medical costs of both palliative treatment modalities, despite the fact that the initial costs of stent placement are much higher than those of brachytherapy. Therefore, cost considerations should not play an important role in decision making on the appropriate palliative treatment strategy for patients with malignant dysphagia.

摘要

自膨式金属支架置入术和单剂量近距离放射治疗常用于缓解因无法手术的食管胃癌导致的食管梗阻。我们将209例患者随机分为置入Ultraflex支架组(n = 108)或单剂量近距离放射治疗组(12 Gy,n = 101)。成本比较包括医院成本、诊断干预和院外护理的综合数据。我们从病例记录表和专科护士每月的家访中获取了有关医疗保健消耗的详细信息。支架置入的初始成本高于近距离放射治疗的成本(1500欧元对570欧元;P<0.001)。然而,总医疗成本相似(支架组11195欧元对近距离放射治疗组10078欧元,P>0.20)。随访期间的总住院天数,支架置入后为11.5天,近距离放射治疗后为12.4天,这导致了两个治疗组较高的院内成本(支架组6512欧元对近距离放射治疗组7982欧元,P>0.20)。随访期间支架置入后的医疗程序成本较高(支架组249欧元对近距离放射治疗组168欧元,P = 0.002),而院外护理成本相似(1278欧元对1046欧元,P>0.20)。总之,尽管支架置入的初始成本远高于近距离放射治疗,但两种姑息治疗方式的总医疗成本之间只有微小差异。因此,成本因素在为恶性吞咽困难患者选择合适的姑息治疗策略的决策中不应起重要作用。

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