新型三酰胺类抗生素泰拉霉素在牛体内的药代动力学及肺组织浓度
Pharmacokinetics and lung tissue concentrations of tulathromycin, a new triamilide antibiotic, in cattle.
作者信息
Nowakowski Marcus A, Inskeep Philip B, Risk Jim E, Skogerboe Terry L, Benchaoui Hafid A, Meinert Todd R, Sherington John, Sunderland Simon J
机构信息
Pfizer Global Research and Development, Groton Laboratories, Veterinary Medicine Safety and Metabolism Group, Eastern Point Road, Groton, CT 06340, USA.
出版信息
Vet Ther. 2004 Spring;5(1):60-74.
The pharmacokinetics of the new triamilide antibiotic tulathromycin was investigated in two cattle studies. Following a single subcutaneous injection, the drug was rapidly absorbed and bioavailability was excellent. High and persistent levels of the drug in lung tissue were observed as well. These attributes are advantageous for an antimicrobial drug indicated for the treatment of bacterial and mycoplasmal respiratory diseases in cattle.
在两项针对牛的研究中对新型三酰胺类抗生素泰拉霉素的药代动力学进行了研究。单次皮下注射后，药物迅速吸收且生物利用度极佳。在肺组织中也观察到药物水平高且持续。这些特性对于一种用于治疗牛细菌性和支原体性呼吸道疾病的抗菌药物来说是有利的。
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