双膦酸盐的使用及随后的抑酸剂处方
Bisphosphonate use and subsequent prescription of acid suppressants.
作者信息
Roughead E E, McGeechan K, Sayer G P
机构信息
Quality Use of Medicines and Pharmacy Research Centre, School of Pharmaceutical Molecular and Biomedical Sciences, University of South Australia, North Terrace, Adelaide 5000, South Australia, Australia.
出版信息
Br J Clin Pharmacol. 2004 Jun;57(6):813-6. doi: 10.1111/j.1365-2125.2004.02078.x.
AIM
To determine the extent of prescribing of acid suppression agents associated with initiation of bisphosphonate therapy.
METHODS
This was a case control study, performed within the General Practice Network, Australia. The main outcome measure was re-attendance within six weeks from index bisphosphonate prescription for acid supression agents.
RESULTS
Of the bisphosphonate cases, 2.9%[95% confidence interval (CI) 1.8, 3.9] returned within 6 weeks for a prescription for proton pump inhibitor, histamine 2 receptor antagonist or antacid, compared with 0.9% of control patients (95% CI 0.5, 1.2). However, the bisphosphonate cases had significantly higher rates of previous use of nonsteroidal anti-inflammatory agents. After controlling for previous nonsteroidal anti-inflammatory drug use, the increased use of acid suppression agents was statistically significant, the odds ratio = 3.21 (95% CI 2.02, 5.11).
CONCLUSION
Bisphosphonate use appears to be associated with increased use of acid suppressant agents within 6 weeks of first supply.
目的
确定与双膦酸盐治疗起始相关的抑酸剂处方情况。
方法
这是一项在澳大利亚全科医疗网络内进行的病例对照研究。主要观察指标是自首次开具双膦酸盐处方起六周内再次就诊开具抑酸剂的情况。
结果
在双膦酸盐治疗组病例中，2.9%[95%置信区间（CI）1.8，3.9]在6周内返回开具质子泵抑制剂、组胺2受体拮抗剂或抗酸剂的处方，而对照组患者为0.9%（95%CI 0.5，1.2）。然而，双膦酸盐治疗组病例既往使用非甾体抗炎药的比例显著更高。在控制既往非甾体抗炎药使用情况后，抑酸剂使用增加具有统计学意义，比值比=3.21（95%CI 2.02，5.11）。
结论
首次使用双膦酸盐后的6周内，使用双膦酸盐似乎与抑酸剂使用增加有关。
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