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[一种用于中风的干细胞疗法]

[A stem cell therapy for stroke].

作者信息

Honmo Osamu

机构信息

Department of Neuresargery, Sapporo Medical University.

出版信息

Rinsho Shinkeigaku. 2003 Nov;43(11):897-9.

Abstract

It has been reported that the adult mammalian harbors stem cells or progenitors that retain the potential for both neural production and differentiation. Recently, several progenitors derived from non-neural samples as well as the neural tissues in humans are thought to be a good candidate for the regenerative medicine. Multipotent embryonic stem cells prepared from the fertilized egg or neural stem cells from fetus may be used as allotransplants. Progenitors derived from adult brain, bone marrow, code blood, or lipid can be used as autotransplants. Bone marrow in adult mammals contains several types of precursor and stem cells such as hematopoietic stem cells, non-hematopoietic stem cells, and other unknown precursor cells. The distinct population of progenitor cells in the bone marrow are thought to retain the potential for both neural production and differentiation, and may contribute to a therapeutic strategy for stroke. In the present report, the possible therapeutic strategy of the stem cell transplantation for the stroke is discussed.

摘要

据报道,成年哺乳动物体内含有具有神经生成和分化潜能的干细胞或祖细胞。最近,来源于非神经样本以及人类神经组织的几种祖细胞被认为是再生医学的良好候选者。从受精卵制备的多能胚胎干细胞或胎儿的神经干细胞可作为同种异体移植。来源于成体脑、骨髓、脐带血或脂肪的祖细胞可作为自体移植。成年哺乳动物的骨髓含有几种类型的前体细胞和干细胞,如造血干细胞、非造血干细胞和其他未知的前体细胞。骨髓中不同群体的祖细胞被认为具有神经生成和分化的潜能,并可能有助于中风的治疗策略。在本报告中,讨论了干细胞移植治疗中风的可能策略。

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