Freitas Claudia Sondermann, Dalmau Sergio Ranto
Instituto National de Cancer, Oncohematology Research Program,Centro de Pesquisa, Rua André Cavalcante 37, 6 andar, Centro, Rio de Janeiro, RJ, CEP 20230-030, Brazil.
Cell Tissue Res. 2006 Sep;325(3):403-11. doi: 10.1007/s00441-006-0172-x. Epub 2006 Apr 13.
A body of evidence points to the existence of stem cell stores in adult tissues, in addition to the well-known hematopoietic stem cells from bone marrow. Many reports describe the ability of these multipotent cells (developmentally non-compromised with their organs of origin) to give rise to many different cell types in response to specific stimuli. This apparent plasticity provides new perspectives in tissue engineering and suggests the usefulness of these cells in future protocols of autologous transplantation, gene therapy, and tissue reconstitution in a number of pathological processes. Lipoaspirates and dermis represent accessible sources for obtaining such cells, with minimal discomfort to the donor, and might be promising candidates for cell therapy procedures once their features are experimentally accessed. The intention of the present work has been to gather reports on the phenotypic characteristics, profile, and plastic potential of these stem cells.
除了众所周知的来自骨髓的造血干细胞外，有大量证据表明成年组织中存在干细胞库。许多报告描述了这些多能细胞（在发育上与其起源器官无冲突）在特定刺激下产生许多不同细胞类型的能力。这种明显的可塑性为组织工程提供了新的视角，并表明这些细胞在未来自体移植、基因治疗以及多种病理过程中的组织重建方案中具有实用性。抽脂物和真皮是获取此类细胞的可及来源，对供体造成的不适最小，一旦通过实验了解其特性，可能成为细胞治疗程序的有前景的候选者。本研究的目的是收集有关这些干细胞的表型特征、概况和可塑性潜能的报告。
