负荷后高血糖是日本男性动脉僵硬度的独立危险因素。

Post-challenge hyperglycaemia is an independent risk factor for arterial stiffness in Japanese men.

作者信息

Ohshita K, Yamane K, Ishida K, Watanabe H, Okubo M, Kohno N

机构信息

Department of Molecular and Internal Medicine, Division of Clinical Medical Science, Programs for Applied Biomedicine, Graduate School of Biomedical Sciences, Hiroshima University, Japan.

出版信息

Diabet Med. 2004 Jun;21(6):636-9. doi: 10.1111/j.1464-5491.2004.01161.x.

DOI:10.1111/j.1464-5491.2004.01161.x

PMID:15154954

Abstract

AIMS

Arterial stiffness is an independent predictor of cardiovascular disease, but the impact of post-challenge hyperglycaemia on arterial stiffness is unknown. To investigate the association between arterial stiffness and post-challenge hyperglycaemia, we measured the second derivative of photoplethysmogram as an indicator of arterial stiffness.

METHODS

This study was done in 159 asymptomatic Japanese men aged 50.7 +/- 13.0 years. All subjects underwent a 75-g oral glucose tolerance test and measurement of the second derivative of photoplethysmogram.

RESULTS

According to the World Health Organization criteria (1998), 110 subjects had normal glucose tolerance, 10 had impaired fasting glucose, 30 had impaired glucose tolerance, and nine had diabetes. The b/a ratio (an index of arterial stiffness) showed a significant relationship with age (r = 0.58, P < 0.0001), height (r = -0.33, P < 0.0001), 2-h post-challenge glucose (r = 0.32, P < 0.0001), systolic blood pressure (r = 0.22, P = 0.006), and diastolic blood pressure (r = 0.21, P = 0.009). After adjustment for age and height, there were significant correlations between the b/a ratio and diastolic blood pressure (r = 0.18, P = 0.02), fasting glucose (r = 0.16, P = 0.049), and 2-h post-challenge glucose (r = 0.21, P = 0.009). Stepwise multiple regression analysis showed that only age (beta= 0.006, SE = 0.0007, P < 0.001) and 2-h post-challenge glucose (beta = 0.0005, SE = 0.0002, P < 0.05) contributed significantly to the b/a ratio (adjusted R(2) = 0.38).

CONCLUSIONS

These results indicate that post-challenge hyperglycaemia is an independent risk factor for arterial stiffness.

摘要

目的

动脉僵硬度是心血管疾病的独立预测指标，但挑战后高血糖对动脉僵硬度的影响尚不清楚。为了研究动脉僵硬度与挑战后高血糖之间的关联，我们测量了光电容积脉搏波的二阶导数作为动脉僵硬度的指标。

方法

本研究纳入了159名年龄为50.7±13.0岁的无症状日本男性。所有受试者均接受了75克口服葡萄糖耐量试验及光电容积脉搏波二阶导数的测量。

结果

根据世界卫生组织标准（1998年），110名受试者糖耐量正常，10名空腹血糖受损，30名糖耐量受损，9名患有糖尿病。b/a比值（动脉僵硬度指标）与年龄（r = 0.58，P < 0.0001）、身高（r = -0.33，P < 0.0001）、挑战后2小时血糖（r = 0.32，P < 0.0001）、收缩压（r = 0.22，P = 0.006）及舒张压（r = 0.21，P = 0.009）均呈显著相关。在对年龄和身高进行校正后，b/a比值与舒张压（r = 0.18，P = 0.02）、空腹血糖（r = 0.16，P = 0.049）及挑战后2小时血糖（r = 0.21，P = 0.009）之间仍存在显著相关性。逐步多元回归分析显示，仅年龄（β = 0.006，SE = 0.0007，P < 0.001）和挑战后2小时血糖（β = 0.0005，SE = 0.0002，P < 0.05）对b/a比值有显著贡献（校正R² = 0.38）。