Baynard Tracy, Carhart R L, Weinstock R S, Ploutz-Snyder L L, Kanaley J A
Exercise Science Department, Syracuse University, NY, 13244, USA.
Eur J Appl Physiol. 2009 Oct;107(3):299-308. doi: 10.1007/s00421-009-1126-2. Epub 2009 Jul 16.
The aim of the study is to determine the effects of short-term high-intensity exercise on arterial function and glucose tolerance in obese individuals with and without the metabolic syndrome (MetSyn). Obese men and women (BMI > 30 kg/m(2); 39-60 years) with and without MetSyn (MetSyn, n = 13; Non-MetSyn, n = 13) participated in exercise training consisting of ten consecutive days of treadmill walking for 1 h/day at 70-75% of peak aerobic capacity. Changes in aerobic capacity, flow-mediated dilation (FMD), and arterial stiffness using central and peripheral pulse wave velocity (PWV) measurements were assessed pre- and post-training. These measurements were obtained fasting and 1-h post-test meal while the subjects were hyperglycemic. Aerobic capacity improved for both groups [Non-MetSyn 24.0 +/- 1.6 vs. 25.1 +/- 1.5 mL/(kg min); MetSyn 25.2 +/- 1.8 vs. 26.2 +/- 1.7 mL/(kg min), P < 0.05]. There was no change in body weight. FMD decreased by ~20% (P < 0.05) for both groups during acute hyperglycemia (MetSyn, n = 11; Non-MetSyn, n = 10), while hyperglycemia increased central PWV and not peripheral PWV. Exercise training did not change FMD in the fasted or challenged state. Central and peripheral PWV were not altered with training for either group (MetSyn, n = 13; Non-MetSyn, n = 13). A 10-day high-intensity exercise program in obese individuals improved aerobic capacity and glucose tolerance but no change in arterial function was observed. Acute hyperglycemia had a deleterious effect on arterial function, suggesting that persons with impaired glucose homeostasis may experience more opportunities for attenuated arterial function on a daily basis which could contribute to increased cardiovascular risk.
本研究的目的是确定短期高强度运动对伴有和不伴有代谢综合征（MetSyn）的肥胖个体动脉功能和糖耐量的影响。伴有和不伴有MetSyn的肥胖男性和女性（BMI>30kg/m²；39 - 60岁）（MetSyn组，n = 13；非MetSyn组，n = 13）参与了运动训练，该训练包括连续十天每天在跑步机上行走1小时，速度为峰值有氧能力的70 - 75%。在训练前后评估有氧能力、血流介导的血管舒张（FMD）以及使用中心和外周脉搏波速度（PWV）测量的动脉僵硬度变化。这些测量在空腹时以及测试餐后1小时进行，此时受试者处于高血糖状态。两组的有氧能力均有所改善[非MetSyn组：24.0±1.6 vs. 25.1±1.5 mL/（kg·min）；MetSyn组：25.2±1.8 vs. 26.2±1.7 mL/（kg·min），P<0.05]。体重没有变化。在急性高血糖期间，两组的FMD均下降了约20%（P<0.05）（MetSyn组，n = 11；非MetSyn组，n = 10），而高血糖增加了中心PWV而非外周PWV。运动训练在空腹或应激状态下并未改变FMD。两组（MetSyn组，n = 13；非MetSyn组，n = 13）的训练均未改变中心和外周PWV。肥胖个体进行的为期10天的高强度运动计划改善了有氧能力和糖耐量，但未观察到动脉功能的变化。急性高血糖对动脉功能有有害影响，这表明葡萄糖稳态受损的人可能在日常生活中更频繁地经历动脉功能减弱，这可能会增加心血管疾病风险。
