γ-谷氨酰乙酰胺（茶氨酸）对小鼠脑梗死的神经保护作用
Neuroprotective effect of gamma-glutamylethylamide (theanine) on cerebral infarction in mice.
作者信息
Egashira Nobuaki, Hayakawa Kazuhide, Mishima Kenichi, Kimura Hitomi, Iwasaki Katsunori, Fujiwara Michihiro
机构信息
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1, Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.
出版信息
Neurosci Lett. 2004 Jun 3;363(1):58-61. doi: 10.1016/j.neulet.2004.03.046.
In the present study, we examined the neuroprotective effect of gamma-glutamylethylamide (theanine) on the ischemic brain damage in a middle cerebral artery occlusion model in mice. Theanine was injected i.p. 3 h after the occlusion or immediately before and 3 h after the occlusion. Theanine (1 mg/kg) significantly decreased the size of the cerebral infarcts 1 day after the occlusion. In contrast, theanine did not affect the cerebral blood flow, brain temperature and physiological variables (pH, pCO(2), pO(2) and hematocrit) in this model. These results suggest that theanine directly provides neuroprotection against focal cerebral ischemia and may be clinically useful for preventing cerebral infarction.
在本研究中，我们在小鼠大脑中动脉闭塞模型中检测了γ-谷氨酰乙酰胺（茶氨酸）对缺血性脑损伤的神经保护作用。在闭塞后3小时或在闭塞前及闭塞后3小时腹腔注射茶氨酸。茶氨酸（1毫克/千克）在闭塞后1天显著减小了脑梗死灶的大小。相比之下，在该模型中茶氨酸不影响脑血流量、脑温度及生理变量（pH、pCO₂、pO₂和血细胞比容）。这些结果表明，茶氨酸可直接为局灶性脑缺血提供神经保护，可能在预防脑梗死方面具有临床应用价值。
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