scopoletin抑制脂多糖刺激的细胞系RAW 264.7细胞产生促炎细胞因子和PGE2 。
Scopoletin suppresses pro-inflammatory cytokines and PGE2 from LPS-stimulated cell line, RAW 264.7 cells.
作者信息
Kim Hyung-Jin, Jang Seon Il, Kim Young-Jun, Chung Hun-Taeg, Yun Yong-Gab, Kang Tai-Hyun, Jeong Ok-Sam, Kim Youn-Chul
机构信息
Immunopia Research Laboratory of Molecular and Cellular Immunology, Wonkwang University, Iksan 570-749, South Korea.
出版信息
Fitoterapia. 2004 Jun;75(3-4):261-6. doi: 10.1016/j.fitote.2003.12.021.
Scopoletin (1-50 microg/ml) inhibited the release of PGE2, TNF-alpha, IL-1beta and IL-6 and suppressed the expression of COX-2 in a concentration-dependent manner. These results suggest that scopoletin might suppress the production of such pro-inflammatory cytokines and exert inhibitory activity on LPS-induced PGE2 production through the depression of COX-2 expression.
东莨菪亭（1-50微克/毫升）以浓度依赖的方式抑制前列腺素E2（PGE2）、肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）和白细胞介素-6（IL-6）的释放，并抑制环氧化酶-2（COX-2）的表达。这些结果表明，东莨菪亭可能通过抑制COX-2的表达来抑制此类促炎细胞因子的产生，并对脂多糖（LPS）诱导的PGE2产生发挥抑制活性。
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