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scopoletin抑制脂多糖刺激的细胞系RAW 264.7细胞产生促炎细胞因子和PGE2 。

Scopoletin suppresses pro-inflammatory cytokines and PGE2 from LPS-stimulated cell line, RAW 264.7 cells.

作者信息

Kim Hyung-Jin, Jang Seon Il, Kim Young-Jun, Chung Hun-Taeg, Yun Yong-Gab, Kang Tai-Hyun, Jeong Ok-Sam, Kim Youn-Chul

机构信息

Immunopia Research Laboratory of Molecular and Cellular Immunology, Wonkwang University, Iksan 570-749, South Korea.

出版信息

Fitoterapia. 2004 Jun;75(3-4):261-6. doi: 10.1016/j.fitote.2003.12.021.

Abstract

Scopoletin (1-50 microg/ml) inhibited the release of PGE2, TNF-alpha, IL-1beta and IL-6 and suppressed the expression of COX-2 in a concentration-dependent manner. These results suggest that scopoletin might suppress the production of such pro-inflammatory cytokines and exert inhibitory activity on LPS-induced PGE2 production through the depression of COX-2 expression.

摘要

东莨菪亭(1-50微克/毫升)以浓度依赖的方式抑制前列腺素E2(PGE2)、肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)和白细胞介素-6(IL-6)的释放,并抑制环氧化酶-2(COX-2)的表达。这些结果表明,东莨菪亭可能通过抑制COX-2的表达来抑制此类促炎细胞因子的产生,并对脂多糖(LPS)诱导的PGE2产生发挥抑制活性。

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