[复发性呼吸道乳头状瘤病患儿人乳头瘤病毒类型的患病率及其对疾病进程的影响]

[Prevalence of human papilloma virus types and their influence on the course of the disease in children suffering from recurrent respiratory papillomatosis].

作者信息

Obchinnikov Iu M, Kiselev V I, Soldatskiĭ Iu L, Artem'ev M I, Onufrieva E K, Baranovskiĭ P M, Shchepin N V, Smetanina S E, Gasparian S F, Steklov A M

出版信息

Vestn Otorinolaringol. 2004(3):29-33.

PMID:15159735

Abstract

The type of human papilloma virus (HPV) was determined in 26 children aged between 1 year 10 months to 15 years 5 months suffering from recurrent respiratory papillomatosis (RRP). Polymerase chain reaction identified DNA of HPV type 6, 11, 16 and 18. HPV DNA was detected in all the patients including fifteen patients infected with HPV type 11; seven patients infected with HPV type 6; four children infected with HPV type 6 and 11. Types 16 and 18 of HPV were not detected. The analysis of RRP course has found that laryngeal papillomatosis runs a more aggressive course in cases with HPV type 11 infection than in those with HPV type 6.

摘要

对26名年龄在1岁10个月至15岁5个月之间患有复发性呼吸道乳头状瘤病（RRP）的儿童进行了人乳头瘤病毒（HPV）类型检测。聚合酶链反应鉴定出HPV 6、11、16和18型的DNA。在所有患者中均检测到HPV DNA，其中15名患者感染了HPV 11型；7名患者感染了HPV 6型；4名儿童同时感染了HPV 6型和11型。未检测到HPV 16和18型。RRP病程分析发现，HPV 11型感染病例的喉乳头状瘤病病程比HPV 6型感染病例更具侵袭性。