Sofola O A, Odusote K A
J Pharmacol Exp Ther. 1976 Jan;196(1):29-34.
The cardiovascular effects of intravenously administered strychnine were studied in anesthetized and paralyzed dogs. Administration of strychnine in cumulative doses of up to 0.1 to 0.2 mg/kg caused significant pressor, as well as positive inotropic and chronotropic, effects on the heart which were abolished by adrenergic blocking agents. The cardiovascular responses possibly were elicited by a central mechanism in contrast to the peripheral inhibitory action of strychnine on the sympathetic system. Diazepam caused a marked attenuation of the pressor response with only slight changes on the heart. A combination of diazepam and propranolol would appear to be a useful therapy in cases of strychnine poisoning showing marked cardiovascular excitation.
在麻醉并麻痹的犬身上研究了静脉注射士的宁的心血管效应。累积剂量高达0.1至0.2mg/kg的士的宁给药对心脏产生了显著的升压作用以及正性肌力和变时性作用，这些作用可被肾上腺素能阻滞剂消除。与士的宁对交感神经系统的外周抑制作用相反，心血管反应可能是由中枢机制引起的。地西泮可显著减弱升压反应，而对心脏仅有轻微影响。在地西泮中毒表现出明显心血管兴奋的情况下，地西泮和普萘洛尔联合使用似乎是一种有效的治疗方法。
