Landgren B M, Hall P E, Cekan S Z
Department of Obstetrics and Gynaecology, Karolinska Hospital, Stockholm, Sweden.
Contraception. 1992 Apr;45(4):343-9. doi: 10.1016/0010-7824(92)90056-y.
Vaginal rings releasing progesterone with 3 different initial release rates (5, 8 and 20 mg/day) were used by 11, 10 and 10 women, respectively. The period of insertion was 90 days. The 5 and 8 mg/day rings consisted of a core loaded with progesterone, the 20 mg/day ring contained progesterone homogeneously distributed throughout the mass of the ring. Notwithstanding these differences, the total progesterone levels (areas under curve) were directly related to the release rates. So were the rates of decrease of progesterone levels during the 90 days of insertion of the ring. They were 25, 31 and 47% for the rings releasing 5, 8 and 20 mg/day, respectively.
分别有11名、10名和10名女性使用了初始释放率不同（分别为5毫克/天、8毫克/天和20毫克/天）的释放孕酮的阴道环。置入期为90天。5毫克/天和8毫克/天的阴道环由装载孕酮的核心部分组成，20毫克/天的阴道环所含孕酮均匀分布于整个环体。尽管存在这些差异，但孕酮的总水平（曲线下面积）与释放率直接相关。在阴道环置入的90天内孕酮水平的下降速率也是如此。释放5毫克/天、8毫克/天和20毫克/天的阴道环的下降速率分别为25%、31%和47%。
