转录后基因表达中的mRNA帽结合蛋白eIF4E
The mRNA cap-binding protein eIF4E in post-transcriptional gene expression.
作者信息
von der Haar Tobias, Gross John D, Wagner Gerhard, McCarthy John E G
机构信息
Post-transcriptional Control Group, Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology, PO Box 88, Manchester M60 1QD, UK.
出版信息
Nat Struct Mol Biol. 2004 Jun;11(6):503-11. doi: 10.1038/nsmb779.
Eukaryotic initiation factor 4E (eIF4E) has central roles in the control of several aspects of post-transcriptional gene expression and thereby affects developmental processes. It is also implicated in human diseases. This review explores the relationship between structural, biochemical and biophysical aspects of eIF4E and its function in vivo, including both long-established roles in translation and newly emerging ones in nuclear export and mRNA decay pathways.
真核生物起始因子4E（eIF4E）在转录后基因表达的多个方面的调控中发挥着核心作用，从而影响发育过程。它还与人类疾病有关。本综述探讨了eIF4E的结构、生化和生物物理方面与其体内功能之间的关系，包括其在翻译中早已确立的作用以及在核输出和mRNA降解途径中新出现的作用。
Zotero 插件