雾化前列环素

Aerosolized prostacyclins.

作者信息

Siobal Mark

机构信息

Respiratory Care Services, San Francisco General Hospital, NH GA-2, 1001 Potrero Avenue, San Francisco, CA 94110, USA.

出版信息

Respir Care. 2004 Jun;49(6):640-52.

PMID:15165299

Abstract

Two prostacyclins (prostaglandin E(1) and prostaglandin I(2)) are potent vasodilators. Aerosolized prostacyclins reduce pulmonary artery pressure, improve right heart function, and increase arterial oxygenation by improving ventilation/perfusion matching. This report describes aerosolized prostacyclins and compares them to inhaled nitric oxide. I review the types of inhalable prostacyclins and their indications, evidence of efficacy, delivery, and adverse effects.

摘要

两种前列环素（前列腺素E(1)和前列腺素I(2)）是强效血管扩张剂。雾化吸入前列环素可降低肺动脉压，改善右心功能，并通过改善通气/血流匹配增加动脉血氧合。本报告描述了雾化吸入前列环素，并将其与吸入一氧化氮进行比较。我回顾了可吸入前列环素的类型及其适应症、疗效证据、给药方式和不良反应。