Lehéricy Stéphane, Ducros Mathieu, Krainik Alexandre, Francois Chantal, Van de Moortele Pierre-François, Ugurbil Kamil, Kim Dae-Shik
Center for Magnetic Resonance Research, University of Minnesota School, Minneapolis, MN, USA.
Cereb Cortex. 2004 Dec;14(12):1302-9. doi: 10.1093/cercor/bhh091. Epub 2004 May 27.
Studies in non-human primates have shown that medial premotor projections to the striatum are characterized as a set of distinct circuits conveying different type of information. This study assesses the anatomical projections from the supplementary motor area (SMA), pre-SMA and motor cortex (MC) to the human striatum using diffusion tensor imaging (DTI) axonal tracking. Eight right-handed volunteers were studied at 1.5 T using DTI axonal tracking. A connectivity matrix was computed, which tested for connections between cortical areas (MC, SMA and pre-SMA) and subcortical areas (posterior, middle and anterior putamen and the head of the caudate nucleus) in each hemisphere. Pre-SMA projections to the striatum were located rostral to SMA projections to the striatum. The SMA and the MC were similarly connected to the posterior and middle putamen and not to the anterior striatum. These data show that the MC and SMA have connections with similar parts of the sensorimotor compartment of the human striatum, whereas the pre-SMA sends connections to more rostral parts of the striatum, including the associative compartment.
对非人类灵长类动物的研究表明，内侧运动前区向纹状体的投射具有一系列不同的回路，这些回路传递不同类型的信息。本研究采用扩散张量成像（DTI）轴突追踪技术，评估辅助运动区（SMA）、前辅助运动区和运动皮层（MC）向人类纹状体的解剖学投射。使用DTI轴突追踪技术在1.5T条件下对8名右利手志愿者进行研究。计算了一个连接矩阵，该矩阵测试了每个半球皮质区域（MC、SMA和前辅助运动区）与皮质下区域（后部、中部和前部壳核以及尾状核头部）之间的连接。前辅助运动区向纹状体的投射位于辅助运动区向纹状体投射的前方。辅助运动区和运动皮层与后部和中部壳核的连接方式相似，而与前部纹状体没有连接。这些数据表明，运动皮层和辅助运动区与人类纹状体感觉运动部分的相似区域有连接，而前辅助运动区则向纹状体更靠前的部分发送连接，包括联合部分。
