Rijcken C A W, Tobi H, Vergouwen A C M, de Jong-van den Berg L T W
Department of Social Pharmacy, Pharmacoepidemiology and Pharmacotherapy, Groningen University Institute of Drug Exploration, The Netherlands.
Pharmacoepidemiol Drug Saf. 2004 Jun;13(6):365-70. doi: 10.1002/pds.951.
In the literature, noncompliance to medication in patients with schizophrenia ranges from 20 to 89%. There is an urgent need for reliable and valid techniques that measure compliance in antipsychotic drug treatment. In this study, we use pharmacy-dispensing records to assess compliance by calculating the refill rate of antipsychotic medication.
Refill rates of chronic antipsychotic drug users in 1999 and in 2000 were established by dividing the number of prescribed days by the total number of calendar days that the patient was registered in a pharmacy prescription records database.
More than 50% of patients using an antipsychotic drug show a refill rate that is associated with medication compliance (0.9-1.1). The number of daily antipsychotic drug intakes was associated with a divergent refill rate, more than once daily dosing was associated with a significantly elevated refill rate (p < 0.015).
The refill rate is a valuable addition to the small arsenal of objective compliance measurement tools. It is an easy to obtain and inexpensive way to estimate (non)compliance. We recommend future studies to medication use in both mental and physical disorders, in order to further specify the actual value of refill rates in clinical practice.
据文献报道，精神分裂症患者的药物治疗不依从率在20%至89%之间。迫切需要可靠且有效的技术来衡量抗精神病药物治疗的依从性。在本研究中，我们利用药房配药记录，通过计算抗精神病药物的再填充率来评估依从性。
通过将1999年和2000年慢性抗精神病药物使用者的处方天数除以该患者在药房处方记录数据库中登记的总日历天数，确定再填充率。
超过50%使用抗精神病药物的患者显示出与药物依从性相关的再填充率（0.9 - 1.1）。每日抗精神病药物的服用次数与不同的再填充率相关，每日多次服药与显著升高的再填充率相关（p < 0.015）。
再填充率是客观依从性测量工具中的一个有价值的补充。它是一种易于获取且成本低廉的估计（不）依从性的方法。我们建议未来对精神疾病和躯体疾病的用药进行研究，以进一步明确再填充率在临床实践中的实际价值。
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