青藤碱衍生物的合成及其抗炎镇痛活性
[Synthesis and anti-inflammatory analgesic activities of sinomenine derivatives].
作者信息
Ye Xian-rong, Yan Ke-xu, Wu Ke-mei, Feng Xiao-zhang, Huang Yu-ming, Qiu Ping
机构信息
Institute of Materia Medica Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China.
出版信息
Yao Xue Xue Bao. 2004 Mar;39(3):180-3.
PMID:15171651
Abstract
AIM
To provide basic data for the synthesis of new sinomenine derivatives.
METHODS
The C ring in sinomenine was modified.
RESULTS
Seven compounds were prepared and screened for anti-inflammatory and analgesic activities. Compounds 2 and 5 showed better activities.
CONCLUSION
Modification of the C ring in sinomenine should be worthy to be studied further.
摘要
目的
为新型青藤碱衍生物的合成提供基础数据。
方法
对青藤碱中的C环进行修饰。
结果
制备了7种化合物，并对其抗炎和镇痛活性进行筛选。化合物2和5表现出较好的活性。
结论
青藤碱中C环的修饰值得进一步研究。
Zotero 插件