Bonde Pramod, Graham Alastair N J, MacGowan Simon W
Department of Cardiac Surgery, Royal Victoria Hospital, Belfast, United Kingdom.
Ann Thorac Surg. 2004 Jun;77(6):2076-82. doi: 10.1016/j.athoracsur.2003.11.001.
Although long saphenous vein remains the most commonly used conduit in coronary revascularization, traditional open vein harvest (OVH) may lead to significantly impaired wound healing and postoperative pain. Endoscopic vein harvest (EVH) attempts to reduce this morbidity and improve patient satisfaction with no compromise in outcome.
From September 2000 to November 2001, 108 saphenous vein harvests were prospectively randomly assigned to EVH (n = 52) or OVH (n = 56); EVH was performed with the Clearglide endoscopic vein harvest system (Cardiovations) by a single surgeon. Endpoints included impaired wound healing (ASEPSIS score), operative and harvest time, vein quality (including histology), outcome and postoperative pain (Visual Analog Scale). Follow-up was as long as 3 years.
The groups were well matched demographically. Endoscopic vein harvest was quicker to perform if sufficient vein for two grafts was needed (p < 0.01). Wound healing was significantly impaired (ASEPSIS score) in the OVH group compared with the EVH group (p < 0.01). The new procedure did not prolong the overall operative time (p = 0.77). Postoperative pain was less (p < 0.01) in the EVH group. Stepwise multiple regression showed age, diabetes, peripheral vascular disease, total operative time, type of procedure, length of incision, and number of vein grafts to be predictive of impaired wound healing. More late interventions were needed in the OVH group for wound-related morbidity.
These data demonstrate that endoscopic vein harvest results in fewer cases of impaired wound healing and reduced postoperative pain, and it does not prolong the operative time significantly nor compromise the vein quality. Furthermore, it is quicker to perform if two grafts are needed, and it reduces late interventions.
尽管大隐静脉仍是冠状动脉血运重建中最常用的血管 conduit,但传统的开放式静脉采集(OVH)可能会导致伤口愈合显著受损和术后疼痛。内镜下静脉采集(EVH)试图降低这种发病率并提高患者满意度,同时不影响治疗效果。
从2000年9月至2001年11月,108例大隐静脉采集手术被前瞻性随机分为EVH组(n = 52)或OVH组(n = 56);EVH手术由一名外科医生使用Clearglide内镜静脉采集系统(Cardiovations)进行。观察指标包括伤口愈合受损情况(ASEPSIS评分)、手术及采集时间、静脉质量(包括组织学)、治疗效果和术后疼痛(视觉模拟评分)。随访时间长达3年。
两组在人口统计学方面匹配良好。如果需要足够的静脉用于两根移植物,内镜下静脉采集的操作速度更快(p < 0.01)。与EVH组相比,OVH组的伤口愈合明显受损(ASEPSIS评分)(p < 0.01)。新方法并未延长总体手术时间(p = 0.77)。EVH组的术后疼痛较轻(p < 0.01)。逐步多元回归分析显示,年龄、糖尿病、外周血管疾病、总手术时间、手术类型、切口长度和静脉移植物数量可预测伤口愈合受损情况。OVH组因伤口相关发病率需要更多的后期干预。
这些数据表明,内镜下静脉采集导致伤口愈合受损的病例较少,术后疼痛减轻,且不会显著延长手术时间,也不会影响静脉质量。此外,如果需要两根移植物,其操作速度更快,并减少了后期干预。