Li Shuang, Chung Eunhee, Quock Raymond M
Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Pullman, WA 99164-6534, USA.
Behav Neurosci. 2004 Jun;118(3):648-52. doi: 10.1037/0735-7044.118.3.648.
Nitric oxide (NO) has been implicated in the anxiolytic-like behavioral effects of nitrous oxide (N2O). This study was conducted to determine whether NO activates a soluble guanylyl cyclase (sGC)-cyclic guanosine monophosphate (cGMP) pathway in the behavioral response to N2O in the light-dark exploration test. In mice pretreated with an sGC inhibitor, the increased light-compartment activity normally induced by N2O was significantly attenuated. Pretreatment with a cGMP phosphodiesterase inhibitor antagonized the anxiogenic effect of 15% N2O and enhanced the anxiolytic effect of 25% N2O, implying that cGMP reduces anxiety. These preliminary findings suggest that a signaling pathway involving NO and cGMP may mediate the behavioral effects of N2O.
一氧化氮（NO）被认为与氧化亚氮（N₂O）的抗焦虑样行为效应有关。本研究旨在确定在明暗箱探索试验中，NO是否通过激活可溶性鸟苷酸环化酶（sGC）-环磷酸鸟苷（cGMP）途径来介导N₂O的行为反应。在用sGC抑制剂预处理的小鼠中，N₂O通常诱导的光箱活动增加显著减弱。用cGMP磷酸二酯酶抑制剂预处理可拮抗15% N₂O的致焦虑作用，并增强25% N₂O的抗焦虑作用，这表明cGMP可减轻焦虑。这些初步研究结果表明，涉及NO和cGMP的信号通路可能介导N₂O的行为效应。
Zotero 插件