Zubal I G, Caride V J
Department of Diagnostic Radiology, Yale University, New Haven, Connecticut 06510.
J Nucl Med. 1992 Sep;33(9):1712-6.
An image-based method for estimating quantitative renal glomerular filtration rates (GFR) by calculating the product of the renal uptake rate and plasma volume is presented. By using the relationship GFR = F.PV/t, F represents renal 99mTc-DTPA uptake after bolus injection, PV is the plasma volume and t is time. This GFR evaluation was carried out on 96 patients and compared to GFR values determined in the same patients using radiotracer blood clearance techniques relying on two venous blood samples. When estimating patient plasma volumes using patient's weight and measured hematocrit values, the image-based method for calculating GFR accurately approximates the values obtained from blood samples (linear regression slope = 1.03; y-intercept = -2.81 ml/min). The two techniques correlate with a value of r = 0.89.
本文提出了一种基于图像的方法，通过计算肾脏摄取率与血浆体积的乘积来估计定量肾肾小球滤过率（GFR）。利用GFR = F.PV/t的关系，F表示推注注射后肾脏对99mTc-DTPA的摄取，PV是血浆体积，t是时间。对96例患者进行了这种GFR评估，并将其与使用依赖于两份静脉血样的放射性示踪剂血液清除技术在同一患者中测定的GFR值进行比较。当使用患者体重和测量的血细胞比容值估计患者血浆体积时，基于图像的计算GFR的方法准确地近似于从血样中获得的值（线性回归斜率 = 1.03；截距 = -2.81 ml/min）。这两种技术的相关系数r = 0.89。
